In the same colectomies, none to occasional CCCs were found in large areas of the mucosa having severe chronic inflammation. The regeneration of ulcers in UC seems to proceed with neo-formation of corrupted crypts. The following CCC phenotypes were found bordering mucosal ulcers: with asymmetric lateral fission (n=11), with dual or three-foiled corrupted fission (n=19), with cystic dilatations (n=3), L-shaped crypts (n=7), T-inverted crypts (n=6), shoe-shaped crypts (n=3), horizontal crypts (n=14), multi-lobate crypts (n=2), and/or inter-connecting crypts (n=5). The review of 49 sections (mean=16.3, range=14-20) in the three colectomies revealed 60 ulcers (mean=20, range=13-27). The mucosa bordering mucosal ulcers was particularly scrutinized. They were called corrupted colonic crypts, CCCs.Īrchival hematoxylin and eosin (H&E)-stained sections from three colectomies having several mucosal ulcers were selected for the study. A recent review of colectomy specimens from patients with UC revealed crypts surrounding mucosal ulcerations exhibiting severe architectural distortions. The histogenesis of colonic crypts with architectural distortions in UC remains elusive. In severe cases, ulcerations are frequently found.
Histology in protracted ulcerative colitis (UC) discloses high numbers of chronic inflammatory cells and crypts with architectural distortions.
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